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Optical Imaging Sampler
Catalogue number: BV311012
This sampler kit includes two economical imaging probes: 5(6)-ROX-RIS and 5(6)-FAM-RIS. Both probes are fluorescen conjugates of risedronate, a widely used bisphosphonate drug in clinical applications. The probes have different spectroscopic properties and can be used for optical microscopy imaging.
Kit Content:
- 24 nmol of 5(6)-FAM-RIS
- 24 nmol of 5(6)-ROX-RIS
- 10 mg of risedronate (optional)
Please contact us for more details about the sampler kit: inquiry@biovinc.net
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This sampler kit includes two economical imaging probes: 5(6)-ROX-RIS and 5(6)-FAM-RIS. Both probes are fluorescent conjugates of risedronate, a widely used bisphosphonate drug in clinical applications. The probes have different spectroscopic properties and can be used for optical microscopy imaging.Spectroscopic properties of 5(6)-ROX-RIS:Maximum absorption wavelength (λmax (abs)): 580 nmMaximum emission wavelength (λmax (em)): 605 nmExtinction coefficient (M-1cm-1): 73,000 (0.1 M phosphate buffer, pH 8.0)Spectroscopic properties of 5(6)-FAM-RIS:Maximum absorption wavelength (λmax (abs)): 493 nmMaximum emission wavelength (λmax (em)): 518 nmExtinction coefficient (M-1cm-1): 73,000 (0.1 M phosphate buffer, pH 7.2)*For laboratory use only. These products are intended for animal research only and not for use in humans.
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Spectroscopic Properties
Emission spectra of 5(6)-FAM-RIS (in 0.1 M phosphate buffer, pH 7.2) and 5(6)-ROX-RIS (in 0.1 M phosphate buffer, pH 8.0) .
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More Info
More Info
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References
- Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo. Roelofs, Anke J.; Coxon, Fraser P.; Ebetino, Frank H.; Lundy, Mark W.; Henneman, Zachary J.; Nancollas, George H.; Sun, Shuting; Blazewska, Katarzyna M.; Bala, Joy Lynn F.; Kashemirov, Boris A.; Khalid, Aysha B.; McKenna, Charles E.; Rogers, Michael J. 2010, Journal of Bone and Mineral Research, 25(3): 606-616.
- Analysing the skeletal distribution of fluorescently-labelled bisphosphonates and lower affinity analogues in vivo. Roelofs, AJ, Boyde, Ebetino FH,A, Lundy, MW, McKenna CE, Blazewska, K, Sun, ST, Kashemirov, BA, Henneman, Z, Nancollas, GH, Russell RGG, Rogers, MJ, Coxon, FP. 2012 Journal of Bone and Mineral Res. 27(4): 835-847.
- Equilibrium-dependant bisphosphonate interaction with crystalline bone mineral explains anti-resorptive pharmacokinetics and prevalenc of osteonecrosis oft he jaw in rats. Hogoku, A, Sun, S, Park, S, McKenna, CE, Nishimura, I. 2013 Bone 53:59-68.
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