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Anti-resorptive Cellular Activity Sampler
Catalogue number: BV315102
This sampler kit includes two probes: 5-FAM-ZOL and AF647-ZOL. 5-FAM-ZOL has in vivo antiresorptive activity and can inhibit protein prenylation of macrophages; and AF647-ZOL has been shown inactive in these studies. This kit is ideal for studies that require imaging probes with and without pharmacological activity.
Kit Content:
- 24 nmol of 5-FAM-ZOL
- 24 nmol of AF647-ZOL
- 10 mg of zoledronate (optional)
Please contact us for more details about the sampler kit: inquiry@biovinc.net
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This sampler kit includes two probes: 5-FAM-ZOL and AF647-ZOL. 5-FAM-ZOL has in vivo antiresorptive activity and can inhibit protein prenylation of macrophages. AF647-ZOL has been shown inactive in these studies. This kit is ideal for studies that require imaging probes with and without pharmacological activity.Spectroscopic properties of 5-FAM-ZOL:Maximum absorption wavelength (λmax (abs)): 493 nmMaximum emission wavelength (λmax (em)): 521 nmExtinction coefficient (M-1cm-1): 73,000 (0.1 M phosphate buffer, pH 7.2)Spectroscopic properties of AF647-ZOL:Maximum absorption wavelength (λmax (abs)): 648 nmMaximum emission wavelength (λmax (em)): 666 nmExtinction coefficient (M-1cm-1): 240,000 (0.1 M phosphate buffer, pH 7.0)*For laboratory use only. These products are intended for animal research only and not for use in humans.
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Spectroscopic Properties
Emission spectra of 5-FAM-ZOL (in 0.1 M phosphate buffer, pH 7.2) and AF647-ZOL (in 0.1 M phosphate buffer, pH 7.0) .
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More Info
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References
- Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo. Roelofs, Anke J.; Coxon, Fraser P.; Ebetino, Frank H.; Lundy, Mark W.; Henneman, Zachary J.; Nancollas, George H.; Sun, Shuting; Blazewska, Katarzyna M.; Bala, Joy Lynn F.; Kashemirov, Boris A.; Khalid, Aysha B.; McKenna, Charles E.; Rogers, Michael J. 2010, Journal of Bone and Mineral Research, 25(3): 606-616.
- Analysing the skeletal distribution of fluorescently-labelled bisphosphonates and lower affinity analogues in vivo. Roelofs, AJ, Boyde, Ebetino FH,A, Lundy, MW, McKenna CE, Blazewska, K, Sun, ST, Kashemirov, BA, Henneman, Z, Nancollas, GH, Russell RGG, Rogers, MJ, Coxon, FP. 2012 Journal of Bone and Mineral Res. 27(4): 835-847.
- Equilibrium-dependant bisphosphonate interaction with crystalline bone mineral explains anti-resorptive pharmacokinetics and prevalenc of osteonecrosis oft he jaw in rats. Hogoku, A, Sun, S, Park, S, McKenna, CE, Nishimura, I. 2013 Bone 53:59-68.
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